Extraction, purification and anti-cancer activity of curcumin
Institute of Biosciences and Technology, MGM University, Aurangabad, Maharashtra, India.
Research Article
Open Access Research Journal of Multidisciplinary Studies, 2022, 04(01), 035–042.
Article DOI: 10.53022/oarjms.2022.4.1.0072
Publication history:
Received on 31 May 2022; revised on 06 July 2022; accepted on 08 July 2022
Abstract:
Turmeric has long been used as a strong anti-inflammatory in Indian drug systems. Turmeric is rich in curcuminoids that have different chemical, physico-chemical properties. Current work reports exraction of curcuminoids, curcumin using the Soxhlet extractor. Purification and quantification of curcumin is performed by chromatography. The yield percentage of curcumin reported 4.09% by the Soxhlet extraction method. Different solvent were used for extraction, among them acetone extract was with high yield of curcumin. Individual curcumin extract analysed using UV-VIS Spectroscopy and HPLC. Our results showed that the Salem turmeric contains highest percentage of curcumin. The in vitroMTT assay on the U87MG glioma cell line demanstrated anti-cancer activity of isolated curcumin.
Keywords:
Turmeric;Curcuminoids; Extraction; Anticancer
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