A review on salivary biomarkers in carcinoma diagnosis

Meena Rakesh Kumar 1, Pabri Reena 2, Singh Prashant 3, Rani Priya 4, Raj Shobhit 5, * and Verma Navneet Kumar 3

1 Department of Medical Biochemistry, NIMS University, Jaipur, Rajasthan, India.
2 Department of Oral Pathology, Government Dental College, Jaipur, Rajasthan, India.
3 Department of Pharmaceutics, Buddha Institute of Pharmacy, GIDA, Gorakhpur, Uttar Pradesh, India.
4 Med. Pharmacology, Department of Pharmacology, National Institute of Medical Sciences & Research, NIMS University, Jaipur, Rajasthan, India.
5 National Institute of Medical Sciences & Research, NIMS University, Jaipur, Rajasthan, India.
 
Review
Open Access Research Journal of Multidisciplinary Studies, 2021, 01(01), 013–021.
Article DOI: 10.53022/oarjms.2021.1.1.0016
Publication history: 
Received on 12 March 2021; revised on 17 April 2021; accepted on 19 April 2021
 
Abstract: 
Carcinoma is the 2nd leading mortality in the U.S. Signs & symptoms include typically unspecific until the tumours metastasize. Hence, an urgency is there for quick, precise, and non-invasive carcinoma diagnosis, rapid detection, diagnosis, stage surveys, & forecasts. Saliva is a multi-structural fluid, found in the oral region, containing secretions from primary and minor salivary glands. Species can even be found in blood-present molecules including Deoxyribo Nucleic Acids, RNAs, hormones, metabolites, and microbiota. Recently, saliva testing received considerable interest in identifying specific biomarkers as sample collection and processing is quick, cost-effective, accurate and doesn’t put any distress on the patient. We examine recent salivary biomarkers of systemic carcinoma by separating them into genomically, transcriptomically, proteomically, metabolomic and microbially dependent forms.
 
Keywords: 
Carcinoma, Deoxyribo Nucleic Acids, RNAs, hormones, metabolites, and microbiota
 
Full text article in PDF: