Effect of Acute Lymphoblastic Leukemia on Hematological and Biochemical Parameters in Children in Najaf, Iraq
Department of Chemistry, Faculty of Science, University of Kufa, Najaf, 54001, Iraq.
Research Article
Open Access Research Journal of Multidisciplinary Studies, 2025, 10(02), 001-008.
Article DOI: 10.53022/oarjms.2025.10.2.0042
Publication history:
Received on 21 August 2025; revised on 26 September 2025; accepted on 30 September 2025
Abstract:
One of the most common childhood cancers is acute lymphoblastic leukemia (ALL). Despite advances in treatment, relapse still occurs in some patients. In ALL, ferritin, lactate dehydrogenase (LDH), and complete blood count (CBC) are essential diagnostic and monitoring markers. Additional liver function tests include serum albumin, SGPT, prothrombin time, and bilirubin.
Aim: In this study, we evaluated the serum levels of prothrombin time, CBC, LDH, ferritin, GH, serum bilirubin, SGPT, serum albumin, and CRP in Iraqi children with acute lymphoblastic leukemia, both before and after achieving clinical remission.
Subjects and Methods: In this study, 90 children were enrolled, including 60 patients (35 boys and 25 girls, aged 10–20 years) with acute lymphoblastic leukemia (ALL) who were attending the National Oncology Teaching Hospital in Najaf, Iraq. Thirty age-matched healthy children (17 boys and 13 girls) served as the control group. The patients were further divided into two subgroups: newly diagnosed (before treatment) and in remission (after treatment). Prothrombin time, serum albumin, ferritin, growth hormone, C-reactive protein (CRP), serum lactate dehydrogenase (LDH), serum bilirubin, and SGPT were measured. The findings revealed that, compared to healthy children, ALL patients had significantly higher ferritin levels (277.3 ± 121.9 ng/ml vs. 67.42 ± 9.33 ng/ml in controls) and LDH levels (694.11 ± 83.3 U/L vs. 183 ± 23.7 U/L in controls) (p < 0.05). In addition, growth hormone activity (9.2 ± 1.9 ng/ml vs. 6.2 ± 2.8 ng/ml) was significantly higher (p ≤ 0.05) in ALL patients prior to treatment compared to those in remission following treatment.
Keywords:
Children; Remission; Leukemia; Acute Lymphoblastic Leukemia; Liver Function
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