AMELIORATIVE EFFECT OF CHRYSIN AGAINST POTASSIUM DICHROMATE-INDUCED NEPHROTOXICITY IN MALE RATS
1 Department of Biology, College of Science, AL-Qasim Green University 51013, Iraq.
2 Department of Biology. College of Science.University of Kerbala.
3 Department of pathological analysis, College of Science, AL-Qasim Green University 51013, Iraq.
* Corresponding Author
Research Article
Open Access Research Journal of Multidisciplinary Studies, 2026, 12(01), 001–009.
Article DOI: 10.53022/oarjms.2026.12.1.0039
Publication history:
Received on 17 July 2026; revised on 25 August 2026; accepted on 27 August 2026
Abstract:
This study investigated the protective effect of Chrysin, a naturally occurring flavone, against potassium dichromate (K₂Cr₂O₇)-induced nephrotoxicity in male Wistar rats. Thirty-two adult rats were allocated to four groups (n = 8 per group): control, potassium dichromate (7.5 mg/kg/day), potassium dichromate + Chrysin low dose (25 mg/kg/day), and potassium dichromate + Chrysin high dose (50 mg/kg/day). Renal function (serum urea, blood urea nitrogen and creatinine), renal oxidative stress and antioxidant status (malondialdehyde, reduced glutathione and superoxide dismutase), and renal histopathology were assessed. Rats exposed to potassium dichromate alone exhibited marked renal dysfunction, with serum creatinine, urea and blood urea nitrogen approximately three-fold, 1.8-fold and 2.3-fold higher, respectively, than controls, together with a pronounced elevation of malondialdehyde and depletion of reduced glutathione, and severe histopathological lesions including glomerular capillary hemorrhage, swelling of the glomerular tuft with obliteration of Bowman’s space, and cloudy swelling of the renal tubules. Superoxide dismutase activity did not differ significantly among groups (P = 0.33). Co-administration of Chrysin produced a dose-dependent improvement in all measured renal function and oxidative stress parameters, with the high dose restoring blood urea nitrogen, serum urea and malondialdehyde to levels statistically indistinguishable from controls, and producing the greatest degree of histological protection, characterized by mild residual tubular degeneration with relatively preserved renal architecture. These findings indicate that Chrysin exerts significant, dose-dependent nephroprotective effects against potassium-dichromate-induced renal injury, most plausibly attributable to its antioxidant and anti-inflammatory properties.
Keywords:
Chrysin, Potassium Dichromate, Nephrotoxicity, Oxidative Stress, Renal Histopathology and Rats
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