Inclusion of routine blood tests to detect the onset of physiological disorders early
Department of Biology, College of Education for Pure Science, University of Samarra, Samarra, Iraq.
Research Article
Open Access Research Journal of Life Sciences, 2026, 11(02), 055-065.
Article DOI: 10.53022/oarjls.2026.11.2.0020
Publication history:
Received on 17 May 2026; revised on 24 June 2026; accepted on 26 June 2026
Abstract:
The initial physiological and metabolic changes can go unnoticed even though they play an important role in the development of metabolic and inflammatory diseases. The current research was performed to evaluate the combined role of routinely tested hematology variables along with biochemical, oxidative stress, and inflammatory indicators.
The total sample size for this cross-sectional study consisted of 100 participants: 50 healthy subjects and 50 individuals who displayed early physiologic/metabolic changes. Hematological measurements were conducted by an automated analyzer while biochemical and hepatic parameters were obtained through laboratory techniques. Other parameters like TAC and MDA levels along with CRP were also analyzed using laboratory procedures. The statistical analyses were carried out using SPSS and Pearson’s correlation coefficient was used to measure correlation among various variables.
Hematologically, significant changes were observed that include increased WBC count and neutrophil to lymphocyte ratio, and decreased hemoglobin and platelet counts in the study subjects. In terms of biochemistry, the study found significantly higher levels of blood glucose, lipids, liver enzymes, and kidney functions. In addition, there was oxidative stress due to elevated malondialdehyde levels and lower total antioxidant capacity. The presence of inflammation was proven through high C-reactive protein values. In correlation analysis, significant correlations were found between inflammatory and oxidative markers, and significant negative correlations between the latter and metabolic and inflammatory variables.
The results show that an initial imbalance in physiology involves a closely interrelated network of hematological, metabolic, oxidative, and inflammatory abnormalities. The combination of the commonly used hematological parameters along with the biochemical and oxidative stress markers might offer a more sensitive means of detecting physiological dysfunction at an early stage.
Keywords:
Hematological parameters; Biochemical markers; Oxidative stress; Malondialdehyde (MDA); C-reactive protein (CRP); Systemic inflammation
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Copyright © 2026 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0