Early detection of subclinical oxidative stress and its correlation with biochemical and haematological indices
1 Department of Biology, College of Science, Tikrit University, Tikrit, Iraq.
2 Department of Clinical Laboratory Sciences, College of Pharmacy, Tikrit University, Tikrit, Iraq.
Research Article
Open Access Research Journal of Life Sciences, 2026, 11(02), 066–076.
Article DOI: 10.53022/oarjls.2026.11.2.0008
Publication history:
Received on 05 March 2026; revised on 06 April 2026; accepted on 09 April 2026
Abstract:
Introduction: There is increasing evidence suggesting that oxidative stress can be considered one of the first events in biology, which may happen in healthy people even before the appearance of any signs of disease. Purpose: The present study was designed to investigate subclinical oxidative stress and the correlation between it and some hematological and biochemical markers in apparently healthy subjects.
Methods: In the present study, 70 apparently healthy subjects were involved and were divided into groups based on their oxidative stress level. MDA and TAC were measured as indices of oxidative stress. Other variables measured were hemoglobin, total leukocyte count, NLR, along with biochemical parameters such as glucose and lipids. All tests were done by routine laboratory methods.
Results: Subjects having higher oxidative stress showed significantly higher MDA levels and significantly lower TAC levels compared to those with low oxidative stress (p<0.001). Higher levels of NLR and CRP indicated mild inflammation. Additionally, there was a significant increase in the fasting glucose, total cholesterol, triglyceride, and LDL cholesterol levels and a significant reduction in the HDL cholesterol level (p<0.001). Significant correlations were seen among the markers of oxidative stress, inflammation, and metabolism.
Conclusion: There is subclinical oxidative stress in apparently healthy subjects associated with early changes in hematological status, inflammation, and metabolism. This implies that oxidative stress markers could be useful early biomarkers of physiological dysfunction.
Keywords:
Oxidative stress; Malondialdehyde; Subclinical inflammation; Metabolic biomarkers; Lipid profile; Glucose.
Full text article in PDF:
Copyright information:
Copyright © 2026 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0