Biological activity of imidazole-based Schiff bases: A review
1 Department of Chemistry, College of Science, University of Kirkuk, Kirkuk, Iraq.
2 Department of Biochemistry, College of Medicine, University of Kirkuk, Kirkuk, Iraq.
Review
Open Access Research Journal of Chemistry and Pharmacy, 2026, 08(02), 005-023.
Article DOI: 10.53022/oarjcp.2026.8.2.0013
Publication history:
Received on 25 March 2026; revised on 01 April 2026; accepted on 07 April 2026
Abstract:
An azole heterocycle that is frequently added to both synthetic and natural compounds is imidazole. It is made up of two nitrogen atoms that are not contiguous. Imidazole derivatives need to have a planar ring structure connected to electron-rich nitrogen donors in order to interact weakly with various bio receptors and enzymes. It is employed as a solution for aqueous solubility, bioavailability, and toxicity characteristics because, as a polar chemical, it improves the pharmacokinetic properties of the pilot molecules. A long-term home has been established for an organic compound comprising imidazole derivatives in the therapeutic and medical fields Consolidating the imidazole unit is a crucial synthetic technique in the drug development process. Due to the enormous therapeutic potential of imidazole-based Schiff bases, scientists are currently focusing on newly produced novel chemotherapeutic medicines, such as anticancer, antibacterial, antioxidant, antiviral, and antileishmanial. In clinical medicine, the extent to which imidazole medications may treat different dispositions has grown. This page covers the design, synthesis, and significance of imidazoles as well as their structural properties. An overview of the documented imidazole-based Schiff bases and their derivatives, which have a great deal of potential applications in medicinal chemistry, is what this research aims to present.
Keywords:
Imidazole; Schiff bases; biological activity; Antifungal; Antibacterial
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Copyright © 2026 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0